Mechanisms by which the p53 tumor suppressor mediates pathological manifestations in Rpl24-heterozygous mice

Title: Mechanisms by which the p53 tumor suppressor mediates pathological manifestations in Rpl24-heterozygous mice
Objectives:
Upregulation of p53 and Sesn2 in Rpl24-heterozygous mice suggests that p53 regulates pathological manifestations of these mice through Sesn2-dependent regulation of autophagy and mTOR signalling pathway.
Our objectives are:
1. To determine if p53-dependent induction…